I have seen some clever interpretation for what is really going on what Pac-Man is really all about, but Drugs by Wilhelm Steiner, is the grimmest I have found. If you think this would be eye-catching on a shirt, make sure to keep an eye on it on Threadless to see what happens.
What do you get when you try to minimize iconic characters to their bare recognized minimums? I have no idea! I am not a designer or an artist, but luckily Eric Slager is and he put his talents to stripping his the Muppets down to their most basic form. The impressive results have been posted at Lost at E Minor.
Here is some great eye-candy for you designer types out there, who might like things a bit more retro. Smashing Magazine collected some great examples of logos and text from vintage and vintage inspire products, which make for some nice coffee break browsing.